Aliphatic aldoxime dehydratase

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In enzymology, an aliphatic aldoxime dehydratase (EC 4.99.1.5) is an enzyme that catalyzes the chemical reaction

an aliphatic aldoxime $\rightleftharpoons$ an aliphatic nitrile + H₂O

Hence, this enzyme has one substrate, aliphatic aldoxime, and two products, aliphatic nitrile and H₂O.

This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming). Other names in common use include OxdA, and aliphatic aldoxime hydro-lyase.

[edit] References

IUBMB entry for 4.99.1.5
BRENDA references for 4.99.1.5 (Recommended.)
PubMed references for 4.99.1.5
PubMed Central references for 4.99.1.5
Google Scholar references for 4.99.1.5
Kobayashi M (2003). "Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23. Sequencing, gene expression, purification, and characterization". J. Biol. Chem. 278: 29600–8. doi:10.1074/jbc.M211832200. PMID 12773527.
Xie SX, Kato Y, Komeda H, Yoshida S, Asano Y (2003). "A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4". Biochemistry. 42: 12056–66. doi:10.1021/bi035092u. PMID 14556637.
Kato Y, Yoshida S, Xie SX, Asano Y (2004). "Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771". J. Biosci. Bioeng. 97: 250–9. PMID 16233624.