Aldose 1-epimerase

From Wikipedia, the free encyclopedia

In enzymology, an aldose 1-epimerase (EC 5.1.3.3) is an enzyme that catalyzes the chemical reaction

alpha-D-glucose $\rightleftharpoons$ beta-D-glucose

Hence, this enzyme has one substrate, alpha-D-glucose, and one product, beta-D-glucose.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is aldose 1-epimerase. Other names in common use include mutarotase, and aldose mutarotase. This enzyme participates in glycolysis and gluconeogenesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes 1L7J, 1L7K, 1LUR, 1MMU, 1MMX, 1MMY, 1MMZ, 1MN0, 1NS0, 1NS2, 1NS4, 1NS7, 1NS8, 1NSM, 1NSR, 1NSS, 1NSU, 1NSV, 1NSX, 1NSZ, 1SNZ, 1SO0, and 1YGA.

[edit] References

IUBMB entry for 5.1.3.3
BRENDA references for 5.1.3.3 (Recommended.)
PubMed references for 5.1.3.3
PubMed Central references for 5.1.3.3
Google Scholar references for 5.1.3.3
Bentley R and Bhate DS (1960). "Mutarotase from Penicillium notatum. I. Purification, assay, and general properties of the enzyme". J. Biol. Chem. 235: 1219–1224.
Bentley R and Bhate DS (1960). "Mutarotase from Penicillium notatum. II. The mechanism of the mutarotation reaction". J. Biol. Chem. 235: 1225–1233.
KEILIN D, HARTREE EF (1952). "Biological catalysis of mutarotation of glucose". Biochem. J. 50: 341–8. PMID 14915955.
LEVY GB, COOK ES (1954). "A rotographic study of mutarotase". Biochem. J. 57: 50–5. PMID 13159947.