ALDOC

From Wikipedia, the free encyclopedia

Aldolase C, fructose-bisphosphate

PDB rendering based on 1xfb.

Available structures: 1xfb

Identifiers

Symbol(s)

ALDOC; ALDC

External IDs

OMIM: 103870 MGI: 101863 HomoloGene: 21073

Gene ontology
Molecular Function:	• fructose-bisphosphate aldolase activity • protein binding • lyase activity
Cellular Component:	• mitochondrion
Biological Process:	• fructose metabolic process • glycolysis • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005165 (mRNA)
NP_005156 (protein)

NM_009657 (mRNA)
NP_033787 (protein)

Location

Chr 17: 23.92 - 23.93 Mb

Chr 11: 78.14 - 78.14 Mb

Pubmed search

[1]

[2]

Aldolase C, fructose-bisphosphate, also known as ALDOC, is a human gene.^[1]

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively.^[1]

[edit] References

^ ^a ^b Entrez Gene: ALDOC aldolase C, fructose-bisphosphate.

[edit] Further reading

Buono P, Mancini FP, Izzo P, Salvatore F (1990). "Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene.". Eur. J. Biochem. 192 (3): 805-11. PMID 2209624.
Rocchi M, Vitale E, Covone A, et al. (1989). "Assignment of human aldolase C gene to chromosome 17, region cen----q21.1.". Hum. Genet. 82 (3): 279-82. PMID 2731939.
Rottmann WH, Deselms KR, Niclas J, et al. (1987). "The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones.". Biochimie 69 (2): 137-45. PMID 3105602.
Buono P, Paolella G, Mancini FP, et al. (1988). "The complete nucleotide sequence of the gene coding for the human aldolase C.". Nucleic Acids Res. 16 (10): 4733. PMID 3267224.
Tolan DR, Niclas J, Bruce BD, Lebo RV (1987). "Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations.". Am. J. Hum. Genet. 41 (5): 907-24. PMID 3674018.
Penhoet E, Rajkumar T, Rutter WJ (1967). "Multiple forms of fructose diphosphate aldolase in mammalian tissues.". Proc. Natl. Acad. Sci. U.S.A. 56 (4): 1275-82. PMID 5230152.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Kim JH, Lee S, Kim JH, et al. (2002). "Phospholipase D2 directly interacts with aldolase via Its PH domain.". Biochemistry 41 (10): 3414-21. PMID 11876650.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Arakaki TL, Pezza JA, Cronin MA, et al. (2005). "Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function.". Protein Sci. 13 (12): 3077-84. doi:10.1110/ps.04915904. PMID 15537755.
Buono P, Barbieri O, Alfieri A, et al. (2005). "Diverse human aldolase C gene promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells of transgenic mice.". FEBS Lett. 578 (3): 337-44. doi:10.1016/j.febslet.2004.11.032. PMID 15589842.
Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.". Mol. Cell 23 (4): 607-18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.