ALDH3A1

From Wikipedia, the free encyclopedia

Aldehyde dehydrogenase 3 family, memberA1

Identifiers

ALDH3A1; ALDH3; ALDHIII; MGC10406

External IDs

OMIM: 100660 MGI: 1353451 HomoloGene: 20175

Gene ontology
Molecular Function:	• aldehyde dehydrogenase (NAD) activity • aldehyde dehydrogenase [NAD(P)+ activity] • alcohol dehydrogenase (NADP+) activity • oxidoreductase activity
Cellular Component:	• endoplasmic reticulum • cytosol
Biological Process:	• aldehyde metabolic process • electron transport • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000691 (mRNA)
NP_000682 (protein)

NM_007436 (mRNA)
NP_031462 (protein)

Location

Chr 17: 19.58 - 19.59 Mb

Chr 11: 61.02 - 61.03 Mb

Pubmed search

[1]

[2]

Aldehyde dehydrogenase 3 family, memberA1, also known as ALDH3A1, is a human gene.^[1]

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic aldehyde substrates. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[1]

[edit] References

^ ^a ^b Entrez Gene: ALDH3A1 aldehyde dehydrogenase 3 family, memberA1.

[edit] Further reading

Yoshida A (1993). "Molecular genetics of human aldehyde dehydrogenase.". Pharmacogenetics 2 (4): 139-47. PMID 1306115.
Vasiliou V, Bairoch A, Tipton KF, Nebert DW (2000). "Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.". Pharmacogenetics 9 (4): 421-34. PMID 10780262.
Hsu LC, Chang WC, Shibuya A, Yoshida A (1992). "Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli.". J. Biol. Chem. 267 (5): 3030-7. PMID 1737758.
Eckey R, Timmann R, Hempel J, et al. (1991). "Biochemical, immunological, and molecular characterization of a "high Km" aldehyde dehydrogenase.". Adv. Exp. Med. Biol. 284: 43-52. PMID 1905102.
Yin SJ, Vagelopoulos N, Wang SL, Jörnvall H (1991). "Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a 'variable' enzyme. 'Variable' and 'constant' enzymes within the alcohol and aldehyde dehydrogenase families.". FEBS Lett. 283 (1): 85-8. PMID 2037078.
Santisteban I, Povey S, West LF, et al. (1986). "Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3.". Ann. Hum. Genet. 49 (Pt 2): 87-100. PMID 4073832.
Teng YS (1981). "Stomach aldehyde dehydrogenase: report of a new locus.". Hum. Hered. 31 (2): 74-7. PMID 7228061.
Dyck LE (1995). "Polymorphism of a class 3 aldehyde dehydrogenase present in human saliva and in hair roots.". Alcohol. Clin. Exp. Res. 19 (2): 420-6. PMID 7625577.
Hiraoka LR, Hsu L, Hsieh CL (1995). "Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13.". Genomics 25 (1): 323-5. PMID 7774944.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Hsu LC, Yoshida A (1993). "Human stomach aldehyde dehydrogenase, ALDH3.". Adv. Exp. Med. Biol. 328: 141-52. PMID 8493892.
Rogers GR, Markova NG, De Laurenzi V, et al. (1997). "Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH).". Genomics 39 (2): 127-35. doi:10.1006/geno.1996.4501. PMID 9027499.
Tsukamoto N, Chang C, Yoshida A (1997). "Mutations associated with Sjögren-Larsson syndrome.". Ann. Hum. Genet. 61 (Pt 3): 235-42. doi:10.1046/j.1469-1809.1997.6130235.x. PMID 9250352.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Rekha GK, Devaraj VR, Sreerama L, et al. (1998). "Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues.". Biochem. Pharmacol. 55 (4): 465-74. PMID 9514081.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Rodriguez-Zavala JS, Weiner H (2002). "Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation.". Biochemistry 41 (26): 8229-37. PMID 12081471.
Yang M, Coles BF, Delongchamp R, et al. (2003). "Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphisms on their expressions in Caucasian lung tissue.". Lung Cancer 38 (1): 15-21. PMID 12367788.