AICDA

From Wikipedia, the free encyclopedia

Activation-induced cytidine deaminase

Identifiers

AICDA; ARP2; AID; CDA2; HIGM2

External IDs

OMIM: 605257 MGI: 1342279 HomoloGene: 7623

Gene ontology
Molecular Function:	• cytidine deaminase activity • zinc ion binding • hydrolase activity • metal ion binding
Cellular Component:	• cellular_component • cytoplasm
Biological Process:	• mRNA processing • B cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020661 (mRNA)
NP_065712 (protein)

NM_009645 (mRNA)
NP_033775 (protein)

Location

Chr 12: 8.65 - 8.65 Mb

Chr 6: 122.52 - 122.53 Mb

Pubmed search

[1]

[2]

Activation-induced cytidine deaminase, also known as AICDA, is a human gene.^[1]

[edit] References

^ Entrez Gene: AICDA activation-induced cytidine deaminase.

[edit] Further reading

Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.". Trends Genet. 19 (4): 207–16. PMID 12683974.
Bransteitter R, Sneeden JL, Allen S, et al. (2006). "First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies.". J. Biol. Chem. 281 (25): 16833–6. doi:10.1074/jbc.R600006200. PMID 16624806.
Muto T, Muramatsu M, Taniwaki M, et al. (2001). "Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.". Genomics 68 (1): 85–8. doi:10.1006/geno.2000.6268. PMID 10950930.
Revy P, Muto T, Levy Y, et al. (2000). "Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).". Cell 102 (5): 565–75. PMID 11007475.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Minegishi Y, Lavoie A, Cunningham-Rundles C, et al. (2001). "Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome.". Clin. Immunol. 97 (3): 203–10. doi:10.1006/clim.2000.4956. PMID 11112359.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Noguchi E, Shibasaki M, Inudou M, et al. (2001). "Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels.". J. Allergy Clin. Immunol. 108 (3): 382–6. doi:10.1067/mai.2001.117456. PMID 11544457.
Martin A, Bardwell PD, Woo CJ, et al. (2002). "Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas.". Nature 415 (6873): 802–6. doi:10.1038/nature714. PMID 11823785.
Rada C, Jarvis JM, Milstein C (2002). "AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7003–8. doi:10.1073/pnas.092160999. PMID 12011459.
Petersen-Mahrt SK, Harris RS, Neuberger MS (2002). "AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.". Nature 418 (6893): 99–103. doi:10.1038/nature00862. PMID 12097915.
Dudley DD, Manis JP, Zarrin AA, et al. (2002). "Internal IgH class switch region deletions are position-independent and enhanced by AID expression.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 9984–9. doi:10.1073/pnas.152333499. PMID 12114543.
Martin A, Scharff MD (2002). "Somatic hypermutation of the AID transgene in B and non-B cells.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12304–8. doi:10.1073/pnas.192442899. PMID 12202747.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Greeve J, Philipsen A, Krause K, et al. (2003). "Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas.". Blood 101 (9): 3574–80. doi:10.1182/blood-2002-08-2424. PMID 12511417.
Oppezzo P, Vuillier F, Vasconcelos Y, et al. (2003). "Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation.". Blood 101 (10): 4029–32. doi:10.1182/blood-2002-10-3175. PMID 12521993.
Bransteitter R, Pham P, Scharff MD, Goodman MF (2003). "Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4102–7. doi:10.1073/pnas.0730835100. PMID 12651944.
Zhu Y, Nonoyama S, Morio T, et al. (2003). "Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase.". J. Med. Dent. Sci. 50 (1): 41–6. PMID 12715918.
Sohail A, Klapacz J, Samaranayake M, et al. (2003). "Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.". Nucleic Acids Res. 31 (12): 2990–4. PMID 12799424.