AHNAK

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AHNAK nucleoprotein (desmoyokin)
Identifiers
Symbol(s) AHNAK; AHNAKRS; MGC5395
External IDs OMIM: 103390 MGI: 1316648 HomoloGene: 67425
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79026 66395
Ensembl ENSG00000124942 n/a
Uniprot Q09666 n/a
Refseq NM_001620 (mRNA)
NP_001611 (protein)		 XM_001052079 (mRNA)
XP_001052079 (protein)
Location Chr 11: 62.02 - 62.07 Mb n/a
Pubmed search [1] [2]

AHNAK nucleoprotein (desmoyokin), also known as AHNAK, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin).

[edit] Further reading

  • Shtivelman E, Cohen FE, Bishop JM (1992). "A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure.". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5472–6. PMID 1608957. 
  • Kudoh J, Wang Y, Minoshima S, et al. (1995). "Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization.". Cytogenet. Cell Genet. 70 (3-4): 218–20. PMID 7789175. 
  • James MR, Richard CW, Schott JJ, et al. (1995). "A radiation hybrid map of 506 STS markers spanning human chromosome 11.". Nat. Genet. 8 (1): 70–6. doi:10.1038/ng0994-70. PMID 7987395. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
  • Gentil BJ, Delphin C, Mbele GO, et al. (2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B.". J. Biol. Chem. 276 (26): 23253–61. doi:10.1074/jbc.M010655200. PMID 11312263. 
  • Sussman J, Stokoe D, Ossina N, Shtivelman E (2001). "Protein kinase B phosphorylates AHNAK and regulates its subcellular localization.". J. Cell Biol. 154 (5): 1019–30. doi:10.1083/jcb.200105121. PMID 11535620. 
  • Wernyj RP, Ewing CM, Isaacs WB (2004). "Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery.". Cell Motil. Cytoskeleton 50 (2): 101–13. doi:10.1002/cm.1044. PMID 11746675. 
  • Hohaus A, Person V, Behlke J, et al. (2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton.". FASEB J. 16 (10): 1205–16. doi:10.1096/fj.01-0855com. PMID 12153988. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Straub BK, Boda J, Kuhn C, et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.". J. Cell. Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Haase H, Pagel I, Khalina Y, et al. (2004). "The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.". FASEB J. 18 (7): 839–41. doi:10.1096/fj.03-0446fje. PMID 15001564. 
  • Lee IH, You JO, Ha KS, et al. (2004). "AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.". J. Biol. Chem. 279 (25): 26645–53. doi:10.1074/jbc.M311525200. PMID 15033986. 
  • Stiff T, Shtivelman E, Jeggo P, Kysela B (2004). "AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation.". DNA Repair (Amst.) 3 (3): 245–56. doi:10.1016/j.dnarep.2003.11.001. PMID 15177040. 
  • Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035. 
  • Haase H, Alvarez J, Petzhold D, et al. (2006). "Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.". FASEB J. 19 (14): 1969–77. doi:10.1096/fj.05-3997com. PMID 16319140. 
  • Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening.". Cell Cycle 5 (6): 641–6. PMID 16582619. 
  • De Seranno S, Benaud C, Assard N, et al. (2007). "Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer.". J. Biol. Chem. 281 (46): 35030–8. doi:10.1074/jbc.M606545200. PMID 16984913. 
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