AGTRAP

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Angiotensin II receptor-associated protein
Identifiers
Symbol(s) AGTRAP; ATRAP; MGC29646
External IDs OMIM: 608729 MGI: 1339977 HomoloGene: 7621
Orthologs
Human Mouse
Entrez 57085 11610
Ensembl ENSG00000177674 ENSMUSG00000029007
Uniprot Q6RW13 Q3U7X6
Refseq NM_001040194 (mRNA)
NP_001035284 (protein)		 NM_009642 (mRNA)
NP_033772 (protein)
Location Chr 1: 11.72 - 11.73 Mb Chr 4: 146.92 - 146.93 Mb
Pubmed search [1] [2]

Angiotensin II receptor-associated protein, also known as AGTRAP, is a human gene.[1]

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: AGTRAP angiotensin II receptor-associated protein.

[edit] Further reading

  • Daviet L, Lehtonen JY, Tamura K, et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.". J. Biol. Chem. 274 (24): 17058-62. PMID 10358057. 
  • Cui T, Nakagami H, Iwai M, et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth.". Biochem. Biophys. Res. Commun. 279 (3): 938-41. doi:10.1006/bbrc.2000.4055. PMID 11162453. 
  • Wang W, Huang Y, Zhou Z, et al. (2002). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap).". Int. J. Biochem. Cell Biol. 34 (1): 93-102. PMID 11733189. 
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 171-84. PMID 12107413. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling.". Mol. Biol. Cell 14 (12): 5038-50. doi:10.1091/mbc.E03-06-0383. PMID 12960423. 
  • Guo DF, Chenier I, Tardif V, et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane.". Biochem. Biophys. Res. Commun. 310 (4): 1254-65. PMID 14559250. 
  • Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells.". J. Biol. Chem. 279 (20): 21109-20. doi:10.1074/jbc.M401544200. PMID 14985364. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.". J. Biol. Chem. 280 (13): 12536-41. doi:10.1074/jbc.M500296200. PMID 15668245. 
  • Tanaka Y, Tamura K, Koide Y, et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy.". FEBS Lett. 579 (7): 1579-86. doi:10.1016/j.febslet.2005.01.068. PMID 15757644. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414. 
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