AFM (gene)

From Wikipedia, the free encyclopedia

Afamin

Identifiers

AFM; ALB2; ALBA; ALF; MGC125338; MGC125339

External IDs

OMIM: 104145 MGI: 2429409 HomoloGene: 881

Gene ontology
Molecular Function:	• transmembrane transporter activity
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001133 (mRNA)
NP_001124 (protein)

NM_145146 (mRNA)
NP_660128 (protein)

Location

Chr 4: 74.57 - 74.59 Mb

Chr 5: 91.59 - 91.63 Mb

Pubmed search

[1]

[2]

Afamin, also known as AFM, is a human gene.^[1]

This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.^[1]

[edit] References

^ ^a ^b Entrez Gene: AFM afamin.

[edit] Further reading

Noppe M, Lowenthal A, Karcher D, Gheuens J (1979). "A two-site immunoradiometric assay for the determination of alpha-albumin.". J. Immunol. Methods 27 (1): 75-81. PMID 37276.
Hansson E, Rönnbäck L, Lowenthal A, Noppe M (1985). "Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis.". Brain Res. 353 (2): 175-85. PMID 4041902.
Lowenthal A, Flament-Durand J, Karcher D, et al. (1982). "Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland.". J. Neurochem. 38 (3): 863-5. PMID 7035619.
Lichenstein HS, Lyons DE, Wurfel MM, et al. (1994). "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family.". J. Biol. Chem. 269 (27): 18149-54. PMID 7517938.
Allard D, Gilbert S, Lamontagne A, et al. (1995). "Identification of rat alpha-albumin and cDNA cloning of its human ortholog.". Gene 153 (2): 287-8. PMID 7875606.
Nishio H, Heiskanen M, Palotie A, et al. (1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription.". J. Mol. Biol. 259 (1): 113-9. doi:10.1006/jmbi.1996.0306. PMID 8648639.
Nishio H, Dugaiczyk A (1996). "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family.". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7557-61. PMID 8755513.
Song YH, Naumova AK, Liebhaber SA, Cooke NE (1999). "Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster.". Genome Res. 9 (6): 581-7. PMID 10400926.
Khan MA, Kumar Y, Tayyab S (2003). "Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin.". Int. J. Biol. Macromol. 30 (3-4): 171-8. PMID 12063119.
Voegele AF, Jerković L, Wellenzohn B, et al. (2003). "Characterization of the vitamin E-binding properties of human plasma afamin.". Biochemistry 41 (49): 14532-8. PMID 12463752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.". Proteomics 4 (2): 454-65. doi:10.1002/pmic.200300556. PMID 14760718.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Jerkovic L, Voegele AF, Chwatal S, et al. (2005). "Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression.". J. Proteome Res. 4 (3): 889-99. doi:10.1021/pr0500105. PMID 15952736.
Hu Y, Malone JP, Fagan AM, et al. (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.". Mol. Cell Proteomics 4 (12): 2000-9. doi:10.1074/mcp.M500207-MCP200. PMID 16199891.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.
Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.". J. Proteome Res. 5 (6): 1493-503. doi:10.1021/pr050492k. PMID 16740002.