AFF3

From Wikipedia, the free encyclopedia

AF4/FMR2 family, member 3

Identifiers

AFF3; LAF4; MLLT2-like

External IDs

OMIM: 601464 MGI: 106927 HomoloGene: 1718

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001025108 (mRNA)
NP_001020279 (protein)

NM_010678 (mRNA)
NP_034808 (protein)

Location

Chr 2: 99.53 - 100.09 Mb

n/a

Pubmed search

[1]

[2]

AF4/FMR2 family, member 3, also known as AFF3, is a human gene.^[1]

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: AFF3 AF4/FMR2 family, member 3.

[edit] Further reading

Ma C, Staudt LM (1996). "LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.". Blood 87 (2): 734–45. PMID 8555498.
Liao X, Ma C, Trask B, et al. (1997). "LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12.". Mamm. Genome 7 (6): 467–8. PMID 8662235.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
von Bergh AR, Beverloo HB, Rombout P, et al. (2002). "LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia.". Genes Chromosomes Cancer 35 (1): 92–6. doi:10.1002/gcc.10091. PMID 12203795.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hiwatari M, Taki T, Taketani T, et al. (2003). "Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23).". Oncogene 22 (18): 2851–5. doi:10.1038/sj.onc.1206389. PMID 12743608.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
To MD, Faseruk SA, Gokgoz N, et al. (2005). "LAF-4 is aberrantly expressed in human breast cancer.". Int. J. Cancer 115 (4): 568–74. doi:10.1002/ijc.20881. PMID 15704140.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.