ADP-glyceromanno-heptose 6-epimerase

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In enzymology, an ADP-L-glycero-D-manno-heptose 6-epimerase (EC 5.1.3.20) is an enzyme that catalyzes the chemical reaction

ADP-D-glycero-D-manno-heptose $\rightleftharpoons$ ADP-L-glycero-D-manno-heptose

Hence, this enzyme has one substrate, ADP-D-glycero-D-manno-heptose, and one product, ADP-L-glycero-D-manno-heptose.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is ADP-L-glycero-D-manno-heptose 6-epimerase. This enzyme participates in lipopolysaccharide biosynthesis. It employs one cofactor, NADP+.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1EQ2.

[edit] References

IUBMB entry for 5.1.3.20
BRENDA references for 5.1.3.20 (Recommended.)
PubMed references for 5.1.3.20
PubMed Central references for 5.1.3.20
Google Scholar references for 5.1.3.20
Ding L, Seto BL, Ahmed SA, Coleman WG Jr (1994). "Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosugar epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase". J. Biol. Chem. 269: 24384–90. PMID 7929099.
Raetz CR (1990). "Biochemistry of endotoxins". Annu. Rev. Biochem. 59: 129–70. PMID 1695830.