ADP-dependent medium-chain-acyl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an ADP-dependent medium-chain-acyl-CoA hydrolase (EC 3.1.2.19) is an enzyme that catalyzes the chemical reaction

acyl-CoA + H₂O CoA + a carboxylate

Thus, the two substrates of this enzyme are acyl-CoA and H₂O, whereas its two products are CoA and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is ADP-dependent-medium-chain-acyl-CoA hydrolase. Other names in common use include medium-chain acyl coenzyme A hydrolase, medium-chain acyl-CoA hydrolase, medium-chain acyl-thioester hydrolase, medium-chain hydrolase, and myristoyl-CoA thioesterase. It employs one cofactor, ADP. At least one compound, NADH is known to inhibit this enzyme.

[edit] References

• IUBMB entry for 3.1.2.19
• BRENDA references for 3.1.2.19 (Recommended.)
• PubMed references for 3.1.2.19
• PubMed Central references for 3.1.2.19
• Google Scholar references for 3.1.2.19
• Alexson SE, Nedergaard J (1988). "A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria". J. Biol. Chem. 263: 13564–71. PMID 2901416. 

[edit] External links

The CAS registry number for this enzyme class is 63363-75-7.

• IUBMB entry for 3.1.2.19

• KEGG entry for 3.1.2.19

• BRENDA entry for 3.1.2.19

• NiceZyme view of 3.1.2.19

• EC2PDB: PDB structures for 3.1.2.19

• PRIAM entry for 3.1.2.19

• PUMA2 entry for 3.1.2.19

• IntEnz: Integrated Enzyme entry for 3.1.2.19

• MetaCyc entry for 3.1.2.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047380: ADP-dependent medium-chain-acyl-CoA hydrolase

• AMIGO entry for GO code 0047380: ADP-dependent medium-chain-acyl-CoA hydrolase