ADFP

From Wikipedia, the free encyclopedia

Adipose differentiation-related protein

Identifiers

ADFP; ADRP; MGC10598

External IDs

Gene ontology
Cellular Component:	• extracellular region • nucleus • cytoplasm • endoplasmic reticulum • lipid particle • plasma membrane
Biological Process:	• long-chain fatty acid transport • sequestering of lipid

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001122 (mRNA)
NP_001113 (protein)

NM_007408 (mRNA)
NP_031434 (protein)

Location

Chr 9: 19.11 - 19.12 Mb

Chr 4: 86.13 - 86.14 Mb

Pubmed search

[1]

[2]

Adipose differentiation-related protein, also known as ADFP, is a human gene.^[1]

Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation^[1]

[edit] References

^ ^a ^b Entrez Gene: ADFP adipose differentiation-related protein.

[edit] Further reading

Jiang HP, Serrero G (1992). "Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein.". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 7856–60. PMID 1518805.
Heid HW, Schnölzer M, Keenan TW (1997). "Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane.". Biochem. J. 320 ( Pt 3): 1025–30. PMID 9003395.
Heid HW, Moll R, Schwetlick I, et al. (1998). "Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases.". Cell Tissue Res. 294 (2): 309–21. PMID 9799447.
Schultz CJ, Torres E, Londos C, Torday JS (2002). "Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (2): L288–96. doi:10.1152/ajplung.00204.2001. PMID 12114189.
Saarikoski ST, Rivera SP, Hankinson O (2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia.". FEBS Lett. 530 (1-3): 186–90. PMID 12387890.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Targett-Adams P, Chambers D, Gledhill S, et al. (2003). "Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein.". J. Biol. Chem. 278 (18): 15998–6007. doi:10.1074/jbc.M211289200. PMID 12591929.
Bildirici I, Roh CR, Schaiff WT, et al. (2004). "The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor.". J. Clin. Endocrinol. Metab. 88 (12): 6056–62. PMID 14671211.
Larigauderie G, Furman C, Jaye M, et al. (2005). "Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis.". Arterioscler. Thromb. Vasc. Biol. 24 (3): 504–10. doi:10.1161/01.ATV.0000115638.27381.97. PMID 14707038.
Nakamura N, Akashi T, Taneda T, et al. (2004). "ADRP is dissociated from lipid droplets by ARF1-dependent mechanism.". Biochem. Biophys. Res. Commun. 322 (3): 957–65. doi:10.1016/j.bbrc.2004.08.010. PMID 15336557.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Robenek H, Lorkowski S, Schnoor M, Troyer D (2005). "Spatial integration of TIP47 and adipophilin in macrophage lipid bodies.". J. Biol. Chem. 280 (7): 5789–94. doi:10.1074/jbc.M407194200. PMID 15545278.
Masuda Y, Itabe H, Odaki M, et al. (2006). "ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells.". J. Lipid Res. 47 (1): 87–98. doi:10.1194/jlr.M500170-JLR200. PMID 16230742.
Tobin KA, Harsem NK, Dalen KT, et al. (2006). "Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line.". J. Lipid Res. 47 (4): 815–23. doi:10.1194/jlr.M500527-JLR200. PMID 16391323.
Dalen KT, Ulven SM, Arntsen BM, et al. (2006). "PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.". J. Lipid Res. 47 (5): 931–43. doi:10.1194/jlr.M500459-JLR200. PMID 16489205.
Ohsaki Y, Maeda T, Maeda M, et al. (2006). "Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft.". Biochem. Biophys. Res. Commun. 347 (1): 279–87. doi:10.1016/j.bbrc.2006.06.074. PMID 16808905.
Larigauderie G, Cuaz-Pérolin C, Younes AB, et al. (2006). "Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation.". FEBS J. 273 (15): 3498–510. doi:10.1111/j.1742-4658.2006.05357.x. PMID 16884492.
Magra AL, Mertz PS, Torday JS, Londos C (2007). "Role of adipose differentiation-related protein in lung surfactant production: a reassessment.". J. Lipid Res. 47 (11): 2367–73. doi:10.1194/jlr.M600157-JLR200. PMID 16936283.
Yao M, Huang Y, Shioi K, et al. (2007). "Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma.". Clin. Cancer Res. 13 (1): 152–60. doi:10.1158/1078-0432.CCR-06-1877. PMID 17200350.
Sarov-Blat L, Kiss RS, Haidar B, et al. (2007). "Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.". Arterioscler. Thromb. Vasc. Biol. 27 (5): 1115–22. doi:10.1161/ATVBAHA.106.138990. PMID 17322100.