Adenosylmethionine hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an adenosylmethionine hydrolase (EC 3.3.1.2) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + H₂O L-homoserine + methylthioadenosine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and H₂O, whereas its two products are L-homoserine and methylthioadenosine.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds involving sulfur (thioether and trialkylsulfonium hydrolases). The systematic name of this enzyme class is S-adenosyl-L-methionine hydrolase. Other names in common use include S-adenosylmethionine cleaving enzyme, methylmethionine-sulfonium-salt hydrolase, and adenosylmethionine lyase.

[edit] References

• IUBMB entry for 3.3.1.2
• BRENDA references for 3.3.1.2 (Recommended.)
• PubMed references for 3.3.1.2
• PubMed Central references for 3.3.1.2
• Google Scholar references for 3.3.1.2
• Mazelis M, Levin B, Mallinson N (1965). "Decomposition of methyl methionine sulfonium salts by a bacterial enzyme". Biochim. Biophys. Acta. 105: 106–14. PMID 5849106. 

[edit] External links

The CAS registry number for this enzyme class is 37288-62-3.

• IUBMB entry for 3.3.1.2

• KEGG entry for 3.3.1.2

• BRENDA entry for 3.3.1.2

• NiceZyme view of 3.3.1.2

• EC2PDB: PDB structures for 3.3.1.2

• PRIAM entry for 3.3.1.2

• PUMA2 entry for 3.3.1.2

• IntEnz: Integrated Enzyme entry for 3.3.1.2

• MetaCyc entry for 3.3.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047626: adenosylmethionine hydrolase

• AMIGO entry for GO code 0047626: adenosylmethionine hydrolase