Adenosyl-fluoride synthase
From Wikipedia, the free encyclopedia
In enzymology, an adenosyl-fluoride synthase (EC 2.5.1.63) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + fluoride
5'-deoxy-5'-fluoroadenosine + L-methionine
Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and fluoride, whereas its two products are 5'-deoxy-5'-fluoroadenosine and L-methionine.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:fluoride adenosyltransferase. This enzyme is also called fluorinase.
[edit] Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1RQP, 1RQR, 2C2W, 2C4T, 2C4U, 2C5B, 2C5H, 2CBX, and 2CC2.
[edit] References
- IUBMB entry for 2.5.1.63
- BRENDA references for 2.5.1.63 (Recommended.)
- PubMed references for 2.5.1.63
- PubMed Central references for 2.5.1.63
- Google Scholar references for 2.5.1.63
- O'Hagan D, Schaffrath C, Cobb SL, Hamilton JT, Murphy CD (2002). "Biochemistry: biosynthesis of an organofluorine molecule". Nature. 416: 279. doi:. PMID 11907567.
- Naismith JH (2004). "Crystal structure and mechanism of a bacterial fluorinating enzyme". Nature. 427: 561–5. doi:. PMID 14765200.
[edit] External links
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