ADCY4

From Wikipedia, the free encyclopedia

Adenylate cyclase 4

Identifiers

External IDs

OMIM: 600292 MGI: 99674 HomoloGene: 23149

Gene ontology
Molecular Function:	• magnesium ion binding • adenylate cyclase activity
Cellular Component:	• intracellular • membrane • integral to membrane • dendrite
Biological Process:	• cAMP biosynthetic process • G-protein signaling, coupled to cAMP nucleotide second messenger • intracellular signaling cascade • cyclic nucleotide biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_139247 (mRNA)
NP_640340 (protein)

NM_080435 (mRNA)
NP_536683 (protein)

Location

Chr 14: 23.86 - 23.87 Mb

Chr 14: 54.72 - 54.74 Mb

Pubmed search

[1]

[2]

Adenylate cyclase 4, also known as ADCY4, is a human gene.^[1]

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals.^[1]

[edit] References

^ ^a ^b Entrez Gene: ADCY4 adenylate cyclase 4.

[edit] Further reading

Edelhoff S, Villacres EC, Storm DR, Disteche CM (1995). "Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.". Mamm. Genome 6 (2): 111-3. PMID 7766992.
Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes.". Hum. Genet. 94 (5): 527-9. PMID 7959689.
Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538-46. PMID 10089566.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629-36. PMID 10807185.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975-82. doi:10.1067/mai.2000.105315. PMID 10808179.
Wong ST, Trinh K, Hacker B, et al. (2000). "Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.". Neuron 27 (3): 487-97. PMID 11055432.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399-407. PMID 11299302.
Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.". J. Clin. Endocrinol. Metab. 86 (9): 4495-503. PMID 11549699.
Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.". J. Virol. 76 (7): 3179-88. PMID 11884542.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.". J. Recept. Signal Transduct. Res. 22 (1-4): 79-110. PMID 12503609.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.