Acyl-(acyl-carrier-protein) desaturase

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In enzymology, an acyl-[acyl-carrier-protein] desaturase (EC 1.14.19.2) is an enzyme that catalyzes the chemical reaction

stearoyl-[acyl-carrier-protein] + reduced acceptor + O₂ $\rightleftharpoons$ oleoyl-[acyl-carrier-protein] + acceptor + 2 H₂O

The 3 substrates of this enzyme are [[stearoyl-[acyl-carrier-protein]]], reduced acceptor, and O₂, whereas its 3 products are [[oleoyl-[acyl-carrier-protein]]], acceptor, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with oxidation of a pair of donors resulting in the reduction of O to two molecules of water. The systematic name of this enzyme class is acyl-[acyl-carrier-protein], hydrogen-donor:oxygen oxidoreductase. Other names in common use include stearyl acyl carrier protein desaturase, and stearyl-ACP desaturase. This enzyme participates in polyunsaturated fatty acid biosynthesis. It employs one cofactor, ferredoxin.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1OQ4, 1OQ7, 1OQ9, 1OQB, and 1ZA0.

[edit] References

IUBMB entry for 1.14.19.2
BRENDA references for 1.14.19.2 (Recommended.)
PubMed references for 1.14.19.2
PubMed Central references for 1.14.19.2
Google Scholar references for 1.14.19.2
Jaworski JG, Stumpf PK (1974). "Fat metabolism in higher plants. Properties of a soluble stearyl-acyl carrier protein desaturase from maturing Carthamus tinctorius". Arch. Biochem. Biophys. 162: 158–65. doi:10.1016/0003-9861(74)90114-3. PMID 4831331.
Nagai J, Bloch K (1968). "Enzymatic desaturation of stearyl acyl carrier protein". J. Biol. Chem. 243: 4626–33. PMID 4300868.