Acyl-(acyl-carrier-protein)-phospholipid O-acyltransferase

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In enzymology, an acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase (EC 2.3.1.40) is an enzyme that catalyzes the chemical reaction

acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine [acyl-carrier protein] + O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine

Thus, the two substrates of this enzyme are acyl-acyl-carrier protein and O-(2-acyl-sn-glycero-3-phospho)ethanolamine, whereas its two products are acyl-carrier protein and O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-[acyl-carrier protein]:O-(2-acyl-sn-glycero-3-phospho)ethanolamine O-acyltransferase. Other names in common use include acyl-[acyl-carrier, protein]:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine, and O-acyltransferase. This enzyme participates in glycerophospholipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.40
• BRENDA references for 2.3.1.40 (Recommended.)
• PubMed references for 2.3.1.40
• PubMed Central references for 2.3.1.40
• Google Scholar references for 2.3.1.40
• Taylor SS, Heath EC (1969). "The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B". J. Biol. Chem. 244: 6605–16. PMID 4902888. 

[edit] External links

The CAS registry number for this enzyme class is 37257-18-4.

• IUBMB entry for 2.3.1.40

• KEGG entry for 2.3.1.40

• BRENDA entry for 2.3.1.40

• NiceZyme view of 2.3.1.40

• EC2PDB: PDB structures for 2.3.1.40

• PRIAM entry for 2.3.1.40

• PUMA2 entry for 2.3.1.40

• IntEnz: Integrated Enzyme entry for 2.3.1.40

• MetaCyc entry for 2.3.1.40

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008779: acyl-[acyl-carrier-protein-phospholipid O-acyltransferase]

• AMIGO entry for GO code 0008779: acyl-[acyl-carrier-protein-phospholipid O-acyltransferase]