Talk:Actibind
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I've cut and pasted this section from the article on Aspergillus niger. Will integrate into this article when time allows, unless someone beats me to it :-) Adrian J. Hunter 13:58, 16 October 2006 (UTC)
[edit] Other Uses
A T2-RNase protein that is produced by A. niger, ACTIBIND, is under investiation and development at Hebrew University of Jerusalem as an anticancer drug. Due to its ability to bind actin and to interfere with cytoskeletal network structure, ACTIBIND inhibits growth of cell extensions and cell migration in cancer and in endothelial cells. In mice, ACTIBIND inhibited HT-29 xenograft tumor development. In rats, it exerted preventive and therapeutic effects on dimethylhydrazine-induced colonic tumors as well as on the degree of tumor vascularization. An article in the journal Cancer, May 15, 2006, suggests that ACTIBIND is an effective anticarcinogenic and antiangiogenic protein.
