Activated protein C resistance
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| Activated protein C resistance Classification and external resources |
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| ICD-9 | 289.81 |
|---|---|
| OMIM | 188055 |
| MeSH | D020016 |
Activated protein C resistance is a hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). This results in an increased risk of venous thrombosis, which can cause heart attacks, strokes, and other problems with circulation.[1]
The disorder can be acquired or inherited, the hereditary form having an autosomal dominant inheritance pattern.[2]
[edit] Pathophysiology
Activated protein C (with protein S as a cofactor) degrades Factor Va and Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave Factor Va and/or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be hereditary or acquired.[3] The best known and most common hereditary form is Factor V Leiden. Acquired forms occur in the presence of elevated Factor VIII concentrations.
[edit] Associated conditions
Up to 64% of patients with venous thromboembolism might have activated protein C resistance.[4]
[edit] References
- ^ Dahlbäck B (2003). "The discovery of activated protein C resistance". J. Thromb. Haemost. 1 (1): 3-9. PMID 12871530.
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 188055
- ^ Nicolaes GA, Dahlbäck B (2003). "Congenital and acquired activated protein C resistance". Semin Vasc Med 3 (1): 33-46. doi:. PMID 15199491.
- ^ Sheppard DR (2000). "Activated protein C resistance: the most common risk factor for venous thromboembolism". J Am Board Fam Pract 13 (2): 111-5. PMID 10764192.
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