ACTR1B

From Wikipedia, the free encyclopedia

ARP1 actin-related protein 1 homolog B, centractin beta (yeast)

Identifiers

ACTR1B; ARP1B; CTRN2

External IDs

OMIM: 605144 MGI: 1917446 HomoloGene: 88728

Gene ontology
Molecular Function:	• nucleotide binding • structural molecule activity • protein binding • ATP binding
Cellular Component:	• cytoplasm • cytoskeleton • dynactin complex

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005735 (mRNA)
NP_005726 (protein)

NM_146107 (mRNA)
NP_666219 (protein)

Location

Chr 2: 97.64 - 97.65 Mb

Chr 1: 36.64 - 36.65 Mb

Pubmed search

[1]

[2]

ARP1 actin-related protein 1 homolog B, centractin beta (yeast), also known as ACTR1B, is a human gene.^[1]

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast).

[edit] Further reading

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1.". Mol. Biol. Cell 14 (7): 2645–54. doi:10.1091/mbc.E03-01-0049. PMID 12857853.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Elsea SH, Clark IB, Juyal RC, et al. (1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridization.". Cytogenet. Cell Genet. 84 (1-2): 48–9. PMID 10343100.
Clark SW, Staub O, Clark IB, et al. (1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.". Mol. Biol. Cell 5 (12): 1301–10. PMID 7696711.
Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes.". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.