ACTN1

From Wikipedia, the free encyclopedia

Actinin, alpha 1

PDB rendering based on 1sjj.

Available structures: 1sjj, 2eyi, 2eyn

Identifiers

Symbol(s)

ACTN1; FLJ40884

External IDs

OMIM: 102575 MGI: 2137706 HomoloGene: 55553

Gene ontology
Molecular Function:	• actin binding • integrin binding • calcium ion binding • protein binding • vinculin binding • actin filament binding
Cellular Component:	• cytoskeleton • focal adhesion • Z disc • pseudopodium
Biological Process:	• regulation of apoptosis • focal adhesion formation • actin filament bundle formation • negative regulation of cell motility

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001102 (mRNA)
NP_001093 (protein)

NM_134156 (mRNA)
NP_598917 (protein)

Location

Chr 14: 68.41 - 68.52 Mb

Chr 12: 81.09 - 81.18 Mb

Pubmed search

[1]

[2]

Actinin, alpha 1, also known as ACTN1, is a human gene.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.^[1]

[edit] See also

Actinin

[edit] References

^ Entrez Gene: ACTN1 actinin, alpha 1.

[edit] Further reading

Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227–30. PMID 8997639.
Menko S, Philp N, Veneziale B, Walker J (1998). "Integrins and development: how might these receptors regulate differentiation of the lens.". Ann. N. Y. Acad. Sci. 842: 36–41. PMID 9599291.
Yürüker B, Niggli V (1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.". J. Cell. Sci. 101 ( Pt 2): 403–14. PMID 1629252.
Tokuue Y, Goto S, Imamura M, et al. (1992). "Transfection of chicken skeletal muscle alpha-actinin cDNA into nonmuscle and myogenic cells: dimerization is not essential for alpha-actinin to bind to microfilaments.". Exp. Cell Res. 197 (2): 158–67. PMID 1720388.
Shoeman RL, Kesselmier C, Mothes E, et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease.". FEBS Lett. 278 (2): 199–203. PMID 1991513.
Nishiyama M, Ozturk M, Frohlich M, et al. (1990). "Expression of human alpha-actinin in human hepatocellular carcinoma.". Cancer Res. 50 (19): 6291–4. PMID 2169343.
Youssoufian H, McAfee M, Kwiatkowski DJ (1990). "Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.". Am. J. Hum. Genet. 47 (1): 62–71. PMID 2349951.
Millake DB, Blanchard AD, Patel B, Critchley DR (1989). "The cDNA sequence of a human placental alpha-actinin.". Nucleic Acids Res. 17 (16): 6725. PMID 2780298.
Dubernard V, Faucher D, Launay JM, Legrand C (1995). "Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein.". FEBS Lett. 364 (2): 109–14. PMID 7750553.
Knudsen KA, Soler AP, Johnson KR, Wheelock MJ (1995). "Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.". J. Cell Biol. 130 (1): 67–77. PMID 7790378.
Glück U, Ben-Ze'ev A (1995). "Modulation of alpha-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells.". J. Cell. Sci. 107 ( Pt 7): 1773–82. PMID 7983147.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Egerton M, Moritz RL, Druker B, et al. (1996). "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.". Biochem. Biophys. Res. Commun. 224 (3): 666–74. doi:10.1006/bbrc.1996.1082. PMID 8713105.
Mukai H, Toshimori M, Shibata H, et al. (1997). "Interaction of PKN with alpha-actinin.". J. Biol. Chem. 272 (8): 4740–6. PMID 9030526.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Hazan RB, Norton L (1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton.". J. Biol. Chem. 273 (15): 9078–84. PMID 9535896.
Bunn RC, Jensen MA, Reed BC (1999). "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton.". Mol. Biol. Cell 10 (4): 819–32. PMID 10198040.
Reinhard M, Zumbrunn J, Jaquemar D, et al. (1999). "An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment.". J. Biol. Chem. 274 (19): 13410–8. PMID 10224105.