Talk:Aconitine

From Wikipedia, the free encyclopedia

	Chemistry Portal Aconitine is within the scope of WikiProject Chemicals, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.
	This article is also supported by WikiProject Chemistry.
Stub	This article has been rated as stub-Class on the quality scale.
Low	This article has been rated as low-importance on the importance scale.
Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need.

	MCB Portal This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme.
Stub	This article has been rated as Stub-Class on the assessment scale.
Low	This article is on a subject of Low-importance within molecular and cellular biology.
Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need.

[edit] SMILES Formula

Should anyone need it, the full formula, with all the chirality hints, is COC[C@]12CN(C)[C@@H]3[C@H]4[C@H](OC)C1[C@@]3([C@H](C[C@H]2O)OC)[C@@H]5C[C@]6(O)[C@@H](OC)[C@H](O)[C@@]4(OC(C)=O)[C@H]5C6OC(=O)c7ccccc7

Stripping out the chirality information, you get the still horrible COCC12CN(C)C3C4C(OC)C1C3(C(CC2O)OC)C5CC6(O)C(OC)C(O)C4(OC(C)=O)C5C6OC(=O)c7ccccc7 —The preceding unsigned comment was added by 71.41.210.146 (talk) 05:19, 28 April 2007 (UTC).

[edit] Moved from article

I've moved to following comment from the article to here. -- Ed (Edgar181) 11:44, 2 February 2008 (UTC)

AS FAR AS I KNOW BELLADONNA, HENBANE ETC. WOULD WORK AS ANTIDOTE'S AS IT WAS BY MIXING ACONITE WITH THEM THAT MEDIEVAL MIDWIVES WERE ABLE TO USE IT TO INDUCE TWILIGHT SLEEP WITHOUT POISONING PEOPLE

[edit] Toxicity in human

"One to ten milligrams per kilogram body weight are said to be deadly to humans."

Ludewig; Regenthal et al. (2007) do list 1.5 - 6 mg aconitine nitrate per os as the lethal dose for a man. This is coherent with figures of other authors, including the classical work of Louis Lewin, Gifte und Vergiftungen (1928), which is considered by many toxicologists as one of the fundamental works of modern toxicology. I myself was teached in lectures, that aconitine is the deadliest alcaloid found in european plants, with dosis leth. singula in order of 5 - 10 mg p.o. I'll change therefore the figure given in the article.--84.163.126.131 (talk) 18:20, 12 February 2008 (UTC)

While certainly, 1 – 10 mg/kg BM p.o. (e.g., 75 - 750 mg for a person of BM = 75 kg) would be lethal, this figure was misleading, because it didn't illustrate the truly high toxicity of aconitine in human. ;) --84.163.126.131 (talk) 18:35, 12 February 2008 (UTC)