ACOX3

From Wikipedia, the free encyclopedia

Acyl-Coenzyme A oxidase 3, pristanoyl

Identifiers

External IDs

OMIM: 603402 MGI: 1933156 HomoloGene: 37792

Gene ontology
Molecular Function:	• acyl-CoA dehydrogenase activity • acyl-CoA oxidase activity • FAD binding
Cellular Component:	• peroxisome
Biological Process:	• electron transport • lipid metabolic process • fatty acid metabolic process • fatty acid beta-oxidation • metabolic process • bile acid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003501 (mRNA)
NP_003492 (protein)

NM_030721 (mRNA)
NP_109646 (protein)

Location

Chr 4: 8.42 - 8.49 Mb

Chr 5: 35.9 - 35.93 Mb

Pubmed search

[1]

[2]

Acyl-Coenzyme A oxidase 3, pristanoyl, also known as ACOX3, is a human gene.^[1]

Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined.^[1]

[edit] References

^ ^a ^b Entrez Gene: ACOX3 acyl-Coenzyme A oxidase 3, pristanoyl.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Vanhove GF, Van Veldhoven PP, Fransen M, et al. (1993). "The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney.". J. Biol. Chem. 268 (14): 10335–44. PMID 8387517.
Vanhooren JC, Marynen P, Mannaerts GP, Van Veldhoven PP (1997). "Evidence for the existence of a pristanoyl-CoA oxidase gene in man.". Biochem. J. 325 ( Pt 3): 593–9. PMID 9271077.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zha S, Ferdinandusse S, Hicks JL, et al. (2005). "Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer.". Prostate 63 (4): 316–23. doi:10.1002/pros.20177. PMID 15599942.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.