ACOT4

From Wikipedia, the free encyclopedia

Acyl-CoA thioesterase 4

Identifiers

ACOT4; PTE-Ib; PTE1B; PTE2B

External IDs

Gene ontology
Molecular Function:	• carboxylesterase activity • palmitoyl-CoA hydrolase activity • hydrolase activity
Cellular Component:	• peroxisome
Biological Process:	• very-long-chain fatty acid metabolic process • long-chain fatty acid metabolic process • succinyl-CoA metabolic process • lipid metabolic process • acyl-CoA metabolic process • butanoic acid metabolic process • dicarboxylic acid metabolic process • short-chain fatty acid metabolic process

Orthologs

Human

Mouse

Refseq

NM_152331 (mRNA)
NP_689544 (protein)

NM_134247 (mRNA)
NP_599008 (protein)

Location

Chr 14: 73.13 - 73.13 Mb

Chr 12: 84.93 - 84.93 Mb

Pubmed search

[1]

[2]

Acyl-CoA thioesterase 4, also known as ACOT4, is a human gene.^[1]

[edit] References

^ Entrez Gene: ACOT4 acyl-CoA thioesterase 4.

[edit] Further reading

Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.". Nature 375 (6534): 754–60. doi:10.1038/375754a0. PMID 7596406.
Hunt MC, Nousiainen SE, Huttunen MK, et al. (1999). "Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism.". J. Biol. Chem. 274 (48): 34317–26. PMID 10567408.
Jones JM, Gould SJ (2000). "Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase.". Biochem. Biophys. Res. Commun. 275 (1): 233–40. doi:10.1006/bbrc.2000.3285. PMID 10944470.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hunt MC, Yamada J, Maltais LJ, et al. (2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.". J. Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
Westin MA, Hunt MC, Alexson SE (2006). "The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.". J. Biol. Chem. 280 (46): 38125–32. doi:10.1074/jbc.M508479200. PMID 16141203.
Hunt MC, Rautanen A, Westin MA, et al. (2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157.