Acetylsalicylate deacetylase

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In enzymology, an acetylsalicylate deacetylase (EC 3.1.1.55) is an enzyme that catalyzes the chemical reaction

acetylsalicylate + H₂O $\rightleftharpoons$ salicylate + acetate

Thus, the two substrates of this enzyme are acetylsalicylate and H₂O, whereas its two products are salicylate and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is acetylsalicylate O-acetylhydrolase. Other names in common use include aspirin esterase, aspirin esterase, acetylsalicylic acid esterase, and aspirin hydrolase.

[edit] References

IUBMB entry for 3.1.1.55
BRENDA references for 3.1.1.55 (Recommended.)
PubMed references for 3.1.1.55
PubMed Central references for 3.1.1.55
Google Scholar references for 3.1.1.55
Ali B, Kaur S (1983). "Mammalian tissue acetylsalicylic acid esterase(s): identification, distribution and discrimination from other esterases". J. Pharmacol. Exp. Ther. 226: 589–94. PMID 6875867.
Kim DH, Yang YS, Jakoby WB (1990). "Aspirin hydrolyzing esterases from rat liver cytosol". Biochem. Pharmacol. 40: 481–7. doi:10.1016/0006-2952(90)90546-W. PMID 2383281.
White KN, Hope DB (1984). "Partial purification and characterization of a microsomal carboxylesterase specific for salicylate esters from guinea-pig liver". Biochim. Biophys. Acta. 785: 138–47. PMID 6704404.