ABRA (gene)

From Wikipedia, the free encyclopedia

Actin-binding Rho activating protein

Identifiers

ABRA; STARS

External IDs

OMIM: 609747 MGI: 2444891 HomoloGene: 34713

Gene ontology
Molecular Function:	• transcription coactivator activity • actin binding
Cellular Component:	• plasma membrane • actin cytoskeleton • sarcomere
Biological Process:	• protein import into nucleus, translocation • transcription • regulation of transcription, DNA-dependent • protein targeting • protein transport • positive regulation of Rho protein signal transduction • positive regulation of transcription • positive regulation of transcription factor activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_139166 (mRNA)
NP_631905 (protein)

NM_175456 (mRNA)
NP_780665 (protein)

Location

Chr 8: 107.84 - 107.85 Mb

Chr 15: 41.7 - 41.7 Mb

Pubmed search

[1]

[2]

Actin-binding Rho activating protein, also known as ABRA, is a human gene.^[1]

[edit] References

^ Entrez Gene: ABRA actin-binding Rho activating protein.

[edit] Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Arai A, Spencer JA, Olson EN (2002). "STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription.". J. Biol. Chem. 277 (27): 24453–9. doi:10.1074/jbc.M202216200. PMID 11983702.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Kuwahara K, Barrientos T, Pipes GC, et al. (2005). "Muscle-specific signaling mechanism that links actin dynamics to serum response factor.". Mol. Cell. Biol. 25 (8): 3173–81. doi:10.1128/MCB.25.8.3173-3181.2005. PMID 15798203.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Kuwahara K, Teg Pipes GC, McAnally J, et al. (2007). "Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.". J. Clin. Invest. 117 (5): 1324–34. doi:10.1172/JCI31240. PMID 17415416.