ABI2

From Wikipedia, the free encyclopedia

Abl interactor 2

Identifiers

ABI2; ABI-2; ABI2B; AIP-1; AblBP3; SSH3BP2; argBPIA; argBPIB

External IDs

OMIM: 606442 MGI: 106913 HomoloGene: 4209

Gene ontology
Molecular Function:	• molecular_function • DNA binding • SH3/SH2 adaptor activity • cytoskeletal adaptor activity • SH3 domain binding • kinase binding
Cellular Component:	• nucleus • cytoplasm • cytoskeleton • cell-cell adherens junction • lamellipodium • filopodium • dendrite
Biological Process:	• cytoskeleton organization and biogenesis • learning and/or memory • biological_process • actin polymerization and/or depolymerization • dendrite development • cell migration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001126750 (mRNA)
XP_001126750 (protein)

NM_198127 (mRNA)
NP_937760 (protein)

Location

Chr 2: 203.9 - 204 Mb

Chr 1: 60.35 - 60.43 Mb

Pubmed search

[1]

[2]

Abl interactor 2, also known as ABI2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ABI2 abl interactor 2.

[edit] Further reading

Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).". Int. J. Mol. Med. 9 (6): 591–5. PMID 12011975.
Dai Z, Pendergast AM (1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.". Genes Dev. 9 (21): 2569–82. PMID 7590236.
Wang B, Mysliwiec T, Krainc D, et al. (1996). "Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.". Oncogene 12 (9): 1921–9. PMID 8649853.
Juang JL, Hoffmann FM (1999). "Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity.". Oncogene 18 (37): 5138–47. doi:10.1038/sj.onc.1202911. PMID 10498863.
Chen B, Borinstein SC, Gillis J, et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes.". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
Machado RD, Pauciulo MW, Fretwell N, et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.". Genomics 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551.
Stradal T, Courtney KD, Rottner K, et al. (2001). "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.". Curr. Biol. 11 (11): 891–5. PMID 11516653.
Huang L, Feng L, Yang L, et al. (2003). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.". Mol. Biol. Rep. 29 (3): 317–23. PMID 12463424.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cao C, Leng Y, Li C, Kufe D (2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response.". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Eastman SW, Martin-Serrano J, Chung W, et al. (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.". J. Biol. Chem. 280 (1): 628–36. doi:10.1074/jbc.M410384200. PMID 15509564.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Luo X, Levens E, Williams RS, Chegini N (2006). "The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta.". Hum. Reprod. 21 (6): 1380–6. doi:10.1093/humrep/del011. PMID 16488906.
Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133.
Li Y, Clough N, Sun X, et al. (2007). "Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.". J. Cell. Sci. 120 (Pt 8): 1436–46. doi:10.1242/jcs.03430. PMID 17389688.