6-hydroxynicotinate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 6-hydroxynicotinate dehydrogenase (EC 1.17.3.3) is an enzyme that catalyzes the chemical reaction

6-hydroxynicotinate + H₂O + O₂ 2,6-dihydroxynicotinate + H₂O₂

The 3 substrates of this enzyme are 6-hydroxynicotinate, H₂O, and O₂, whereas its two products are 2,6-dihydroxynicotinate and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with oxygen as acceptor. The systematic name of this enzyme class is 6-hydroxynicotinate:O2 oxidoreductase. Other names in common use include 6-hydroxynicotinic acid hydroxylase, 6-hydroxynicotinic acid dehydrogenase, and 6-hydroxynicotinate hydroxylase.

[edit] References

• IUBMB entry for 1.17.3.3
• BRENDA references for 1.17.3.3 (Recommended.)
• PubMed references for 1.17.3.3
• PubMed Central references for 1.17.3.3
• Google Scholar references for 1.17.3.3
• Nagel M and Andreesen JR (1989). "Molybdenum-dependent degradation of nicotinic acid by Bacillus sp DSM 2923". FEMS Microbiol. Lett. 59: 147–152. doi:10.1111/j.1574-6968.1989.tb03099.x. 
• Nagel M and Andreesen JR (1990). "Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini". Arch. Microbiol. 154: 605–613. 

[edit] External links

• IUBMB entry for 1.17.3.3

• KEGG entry for 1.17.3.3

• BRENDA entry for 1.17.3.3

• NiceZyme view of 1.17.3.3

• EC2PDB: PDB structures for 1.17.3.3

• PRIAM entry for 1.17.3.3

• PUMA2 entry for 1.17.3.3

• IntEnz: Integrated Enzyme entry for 1.17.3.3

• MetaCyc entry for 1.17.3.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043732: 6-hydroxynicotinate dehydrogenase

• AMIGO entry for GO code 0043732: 6-hydroxynicotinate dehydrogenase