4-hydroxybenzoate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a 4-hydroxybenzoate decarboxylase (EC 4.1.1.61) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzoate phenol + CO₂

Hence, this enzyme has one substrate, 4-hydroxybenzoate, and two products, phenol and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxybenzoate carboxy-lyase (phenol-forming). Other names in common use include p-hydroxybenzoate decarboxylase, and 4-hydroxybenzoate carboxy-lyase. This enzyme participates in benzoate degradation via coa ligation.

[edit] References

• IUBMB entry for 4.1.1.61
• BRENDA references for 4.1.1.61 (Recommended.)
• PubMed references for 4.1.1.61
• PubMed Central references for 4.1.1.61
• Google Scholar references for 4.1.1.61
• Grant DJW and Patel JC (1969). "Non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid, and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes)". J. Microbiol. Serol. 35: 325–343. 
• Tschech A and Fuchs G (1989). "Anaerobic degradation of phenol via carboxylation to 4-hydroxybenzoate - in vitro study of isotope exchange between (CO2)-C-14 and 4-hydroxybenzoate". Arch. Microbiol. 152: 594–599. doi:10.1007/BF00425493. 

[edit] External links

The CAS registry number for this enzyme class is 37290-53-2.

• IUBMB entry for 4.1.1.61

• KEGG entry for 4.1.1.61

• BRENDA entry for 4.1.1.61

• NiceZyme view of 4.1.1.61

• EC2PDB: PDB structures for 4.1.1.61

• PRIAM entry for 4.1.1.61

• PUMA2 entry for 4.1.1.61

• IntEnz: Integrated Enzyme entry for 4.1.1.61

• MetaCyc entry for 4.1.1.61

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018799: 4-hydroxybenzoate decarboxylase

• AMIGO entry for GO code 0018799: 4-hydroxybenzoate decarboxylase