4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

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In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.4.3) is an enzyme that catalyzes the chemical reaction

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H₂O + protein-disulfide 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol

The 3 substrates of this enzyme are (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate, H₂O, and protein disulfide, whereas its two products are 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and protein dithiol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 group with a disulfide as acceptor. The systematic name of this enzyme class is (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating). This enzyme participates in biosynthesis of steroids.

[edit] References

• IUBMB entry for 1.17.4.3
• BRENDA references for 1.17.4.3 (Recommended.)
• PubMed references for 1.17.4.3
• PubMed Central references for 1.17.4.3
• Google Scholar references for 1.17.4.3
• D, Rohdich F (2001). "Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein". Proc. Natl. Acad. Sci. U. S. A. 98: 14837–42. doi:10.1073/pnas.201399298. PMID 11752431. 

[edit] External links

• IUBMB entry for 1.17.4.3

• KEGG entry for 1.17.4.3

• BRENDA entry for 1.17.4.3

• NiceZyme view of 1.17.4.3

• EC2PDB: PDB structures for 1.17.4.3

• PRIAM entry for 1.17.4.3

• PUMA2 entry for 1.17.4.3

• IntEnz: Integrated Enzyme entry for 1.17.4.3

• MetaCyc entry for 1.17.4.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0046429: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

• AMIGO entry for GO code 0046429: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase