4-chlorobenzoyl-CoA dehalogenase

From Wikipedia, the free encyclopedia

In enzymology, a 4-chlorobenzoyl-CoA dehalogenase (EC 3.8.1.7) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoyl-CoA + H₂O 4-hydroxybenzoyl CoA + chloride

Thus, the two substrates of this enzyme are 4-chlorobenzoyl-CoA and H₂O, whereas its two products are 4-hydroxybenzoyl CoA and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoyl CoA chlorohydrolase. This enzyme participates in 2,4-dichlorobenzoate degradation.

[edit] References

• IUBMB entry for 3.8.1.7
• BRENDA references for 3.8.1.7 (Recommended.)
• PubMed references for 3.8.1.7
• PubMed Central references for 3.8.1.7
• Google Scholar references for 3.8.1.7
• Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D (1992). "Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3". Biochemistry. 31: 5605–10. doi:10.1021/bi00139a025. PMID 1610806. 
• Crooks GP, Copley SD (1994). "Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1". Biochemistry. 33: 11645–9. doi:10.1021/bi00204a028. PMID 7918379. 

[edit] External links

The CAS registry number for this enzyme class is 141583-18-8.

• IUBMB entry for 3.8.1.7

• KEGG entry for 3.8.1.7

• BRENDA entry for 3.8.1.7

• NiceZyme view of 3.8.1.7

• EC2PDB: PDB structures for 3.8.1.7

• PRIAM entry for 3.8.1.7

• PUMA2 entry for 3.8.1.7

• IntEnz: Integrated Enzyme entry for 3.8.1.7

• MetaCyc entry for 3.8.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018787: 4-chlorobenzoyl-CoA dehalogenase

• AMIGO entry for GO code 0018787: 4-chlorobenzoyl-CoA dehalogenase