3'-demethylstaurosporine O-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a 3'-demethylstaurosporine O-methyltransferase (EC 2.1.1.139) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3'-demethylstaurosporine S-adenosyl-L-homocysteine + staurosporine

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-demethylstaurosporine, whereas its two products are S-adenosylhomocysteine and staurosporine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase. Other names in common use include 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, and staurosporine synthase.

[edit] References

• IUBMB entry for 2.1.1.139
• BRENDA references for 2.1.1.139 (Recommended.)
• PubMed references for 2.1.1.139
• PubMed Central references for 2.1.1.139
• Google Scholar references for 2.1.1.139
• Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zahner H (Tokyo). "3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine". J. Antibiot.: 679–82. PMID 9727395. 

[edit] External links

• IUBMB entry for 2.1.1.139

• KEGG entry for 2.1.1.139

• BRENDA entry for 2.1.1.139

• NiceZyme view of 2.1.1.139

• EC2PDB: PDB structures for 2.1.1.139

• PRIAM entry for 2.1.1.139

• PUMA2 entry for 2.1.1.139

• IntEnz: Integrated Enzyme entry for 2.1.1.139

• MetaCyc entry for 2.1.1.139

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030793: 3'-demethylstaurosporine O-methyltransferase

• AMIGO entry for GO code 0030793: 3'-demethylstaurosporine O-methyltransferase