3-oxoadipyl-CoA thiolase

From Wikipedia, the free encyclopedia

In enzymology, a 3-oxoadipyl-CoA thiolase (EC 2.3.1.174) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + acetyl-CoA CoA + 3-oxoadipyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and acetyl-CoA, whereas its two products are CoA and 3-oxoadipyl-CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:acetyl-CoA C-succinyltransferase. This enzyme participates in benzoate degradation via hydroxylation.

[edit] References

• IUBMB entry for 2.3.1.174
• BRENDA references for 2.3.1.174 (Recommended.)
• PubMed references for 2.3.1.174
• PubMed Central references for 2.3.1.174
• Google Scholar references for 2.3.1.174
• Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184: 207–15. PMID 11741862. 
• Gobel M, Kassel-Cati K, Schmidt E, Reineke W (2002). "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184: 216–23. PMID 11741863. 

[edit] External links

• IUBMB entry for 2.3.1.174

• KEGG entry for 2.3.1.174

• BRENDA entry for 2.3.1.174

• NiceZyme view of 2.3.1.174

• EC2PDB: PDB structures for 2.3.1.174

• PRIAM entry for 2.3.1.174

• PUMA2 entry for 2.3.1.174

• IntEnz: Integrated Enzyme entry for 2.3.1.174

• MetaCyc entry for 2.3.1.174

• Atomic-resolution structures of enzymes belonging to this class