3-hydroxybutyryl-CoA dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) is an enzyme that catalyzes the chemical reaction

(3R)-3-hydroxybutanoyl-CoA crotonoyl-CoA + H₂O

Hence, this enzyme has one substrate, (3R)-3-hydroxybutanoyl-CoA, and two products, crotonoyl-CoA and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming). Other names in common use include D-3-hydroxybutyryl coenzyme A dehydratase, D-3-hydroxybutyryl-CoA dehydratase, enoyl coenzyme A hydrase (D), and (3R)-3-hydroxybutanoyl-CoA hydro-lyase. This enzyme participates in butanoate metabolism.

[edit] References

• IUBMB entry for 4.2.1.55
• BRENDA references for 4.2.1.55 (Recommended.)
• PubMed references for 4.2.1.55
• PubMed Central references for 4.2.1.55
• Google Scholar references for 4.2.1.55
• Moskowitz GJ, Merrick JM (1969). "Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum". Biochemistry. 8: 2748–55. doi:10.1021/bi00835a009. PMID 5808333. 

[edit] External links

The CAS registry number for this enzyme class is 37290-82-7.

• IUBMB entry for 4.2.1.55

• KEGG entry for 4.2.1.55

• BRENDA entry for 4.2.1.55

• NiceZyme view of 4.2.1.55

• EC2PDB: PDB structures for 4.2.1.55

• PRIAM entry for 4.2.1.55

• PUMA2 entry for 4.2.1.55

• IntEnz: Integrated Enzyme entry for 4.2.1.55

• MetaCyc entry for 4.2.1.55

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003859: 3-hydroxybutyryl-CoA dehydratase

• AMIGO entry for GO code 0003859: 3-hydroxybutyryl-CoA dehydratase