3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase (EC 4.1.1.51) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methylpyridine-4,5-dicarboxylate 3-hydroxy-2-methylpyridine-5-carboxylate + CO₂

Hence, this enzyme has one substrate, 3-hydroxy-2-methylpyridine-4,5-dicarboxylate, and two products, 3-hydroxy-2-methylpyridine-5-carboxylate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming). This enzyme is also called 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase. This enzyme participates in vitamin b6 metabolism.

[edit] References

• IUBMB entry for 4.1.1.51
• BRENDA references for 4.1.1.51 (Recommended.)
• PubMed references for 4.1.1.51
• PubMed Central references for 4.1.1.51
• Google Scholar references for 4.1.1.51
• Snell EE, Smucker AA, Ringelmann E and Lynen F (1964). "Die bakterielle Oxydation des Vitamin B6. IV. Die enzymatische Decarboxylierung von 2-Methyl-3-hydroxypyridine-4,5-dicarbonsaure". Biochem. Z. 341: 109–119. 

[edit] External links

The CAS registry number for this enzyme class is 37289-49-9.

• IUBMB entry for 4.1.1.51

• KEGG entry for 4.1.1.51

• BRENDA entry for 4.1.1.51

• NiceZyme view of 4.1.1.51

• EC2PDB: PDB structures for 4.1.1.51

• PRIAM entry for 4.1.1.51

• PUMA2 entry for 4.1.1.51

• IntEnz: Integrated Enzyme entry for 4.1.1.51

• MetaCyc entry for 4.1.1.51

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047431: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase

• AMIGO entry for GO code 0047431: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase