3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase

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In enzymology, a 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase (EC 2.1.1.99) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3-hydroxy-16-methoxy-2,3-dihydrotabersonine $\rightleftharpoons$ S-adenosyl-L-homocysteine + deacetoxyvindoline

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3-hydroxy-16-methoxy-2,3-dihydrotabersonine, whereas its two products are S-adenosylhomocysteine and deacetoxyvindoline.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase. Other names in common use include 16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase, NMT, 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase, S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine, and N-methyltransferase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

IUBMB entry for 2.1.1.99
BRENDA references for 2.1.1.99 (Recommended.)
PubMed references for 2.1.1.99
PubMed Central references for 2.1.1.99
Google Scholar references for 2.1.1.99
Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6: 2726–32. doi:10.1002/pmic.200500419. PMID 16526094.
Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6: 2726–32. doi:10.1002/pmic.200500419. PMID 16526094.