3-deoxy-7-phosphoheptulonate synthase

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In enzymology, a 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + D-erythrose 4-phosphate + H₂O $\rightleftharpoons$ 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate

The 3 substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H₂O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming). Other names in common use include 2-dehydro-3-deoxy-phosphoheptonate aldolase, 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase, 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase, 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate, lyase (pyruvate-phosphorylating), 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate, D-erythrose-4-phosphate lyase (pyruvate-phosphorylating), D-erythrose-4-phosphate-lyase, D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating), DAH7-P synthase, DAHP synthase, DS-Co, DS-Mn, KDPH synthase, KDPH synthetase, deoxy-D-arabino-heptulosonate-7-phosphate synthetase, phospho-2-dehydro-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptanoate aldolase, phospho-2-keto-3-deoxyheptonate aldolase, phospho-2-keto-3-deoxyheptonic aldolase, and phospho-2-oxo-3-deoxyheptonate aldolase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. It employs one cofactor, cadmium.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1RZM, 1VR6, 1VS1, and 2B7O.

[edit] References

IUBMB entry for 2.5.1.54
BRENDA references for 2.5.1.54 (Recommended.)
PubMed references for 2.5.1.54
PubMed Central references for 2.5.1.54
Google Scholar references for 2.5.1.54
Srinivasan PR and Sprinson DB (1959). "2-Keto-3-deoxy-D-arabo-heptonic acid 7-phosphate synthetase". J. Biol. Chem. 234: 716–722.
Jossek R, Bongaerts J, Sprenger GA (2001). "Characterization of a new feedback-resistant 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroF of Escherichia coli". FEMS. Microbiol. Lett. 202: 145–8. PMID 11506923.
Schneider TR, Hartmann M, Braus GH (Pt 9). "Crystallization and preliminary X-ray analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (tyrosine inhibitable) from Saccharomyces cerevisiae". Acta. Crystallogr. D. Biol. Crystallogr. 55: 1586–8. doi:10.1107/S0907444999007830. PMID 10489454.