3-dehydroquinate dehydratase

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In enzymology, a 3-dehydroquinate dehydratase (EC 4.2.1.10) is an enzyme that catalyzes the chemical reaction

3-dehydroquinate $\rightleftharpoons$ 3-dehydroshikimate + H₂O

Hence, this enzyme has one substrate, 3-dehydroquinate, and two products, 3-dehydroshikimate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming). Other names in common use include 3-dehydroquinate hydrolase, DHQase, dehydroquinate dehydratase, 3-dehydroquinase, 5-dehydroquinase, dehydroquinase, 5-dehydroquinate dehydratase, 5-dehydroquinate hydro-lyase, and 3-dehydroquinate hydro-lyase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 26 structures have been solved for this class of enzymes, with PDB accession codes 1D0I, 1GQN, 1GQO, 1GTZ, 1GU0, 1GU1, 1H05, 1H0R, 1H0S, 1J2Y, 1L9W, 1QFE, 1SFJ, 1SFL, 1UQR, 1V1J, 2BT4, 2C4V, 2C4W, 2C57, 2CJF, 2DHQ, 2EGZ, 2GPT, 2OCZ, and 2YR1.

[edit] References

IUBMB entry for 4.2.1.10
BRENDA references for 4.2.1.10 (Recommended.)
PubMed references for 4.2.1.10
PubMed Central references for 4.2.1.10
Google Scholar references for 4.2.1.10
MITSUHASHI S, DAVIS BD (1954). "Aromatic biosynthesis. XII. Conversion of 5-dehydroquinic acid to 5-dehydroshikimic acid dy 5-dehydroquinase". Biochim. Biophys. Acta. 15: 54–61. doi:10.1016/0006-3002(54)90093-1. PMID 13198937.
MITSUHASHI S, DAVIS BD (1954). "Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase". Biochim. Biophys. Acta. 15: 268–80. doi:10.1016/0006-3002(54)90069-4. PMID 13208693.