2alpha-hydroxytaxane 2-O-benzoyltransferase

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In enzymology, a 2alpha-hydroxytaxane 2-O-benzoyltransferase (EC 2.3.1.166) is an enzyme that catalyzes the chemical reaction

benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III CoA + 10-deacetylbaccatin III

Thus, the two substrates of this enzyme are benzoyl-CoA and 10-deacetyl-2-debenzoylbaccatin III, whereas its two products are CoA and 10-deacetylbaccatin III.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase. This enzyme is also called benzoyl-CoA:taxane 2alpha-O-benzoyltransferase. This enzyme participates in diterpenoid biosynthesis.

[edit] References

• IUBMB entry for 2.3.1.166
• BRENDA references for 2.3.1.166 (Recommended.)
• PubMed references for 2.3.1.166
• PubMed Central references for 2.3.1.166
• Google Scholar references for 2.3.1.166
• Walker K, Croteau R (2000). "Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli". Proc. Natl. Acad. Sci. U. S. A. 97: 13591–6. PMID 11095755. 

[edit] External links

The CAS registry number for this enzyme class is 329318-50-5.

• IUBMB entry for 2.3.1.166

• KEGG entry for 2.3.1.166

• BRENDA entry for 2.3.1.166

• NiceZyme view of 2.3.1.166

• EC2PDB: PDB structures for 2.3.1.166

• PRIAM entry for 2.3.1.166

• PUMA2 entry for 2.3.1.166

• IntEnz: Integrated Enzyme entry for 2.3.1.166

• MetaCyc entry for 2.3.1.166

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050642: 2-alpha-hydroxytaxane 2-O-benzoyltransferase

• AMIGO entry for GO code 0050642: 2-alpha-hydroxytaxane 2-O-benzoyltransferase