2-oxoglutarate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a 2-oxoglutarate decarboxylase (EC 4.1.1.71) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate succinate semialdehyde + CO₂

Hence, this enzyme has one substrate, 2-oxoglutarate, and two products, succinate semialdehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming). Other names in common use include oxoglutarate decarboxylase, alpha-ketoglutarate decarboxylase, alpha-ketoglutaric decarboxylase, oxoglutarate decarboxylase, pre-2-oxoglutarate decarboxylase, and 2-oxoglutarate carboxy-lyase. It employs one cofactor, thiamin diphosphate.

[edit] References

• IUBMB entry for 4.1.1.71
• BRENDA references for 4.1.1.71 (Recommended.)
• PubMed references for 4.1.1.71
• PubMed Central references for 4.1.1.71
• Google Scholar references for 4.1.1.71
• Shigeoka S, Onishi T, Maeda K, Nakano Y and Kitaoka S (1986). "Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis". FEBS Lett. 195: 43–47. doi:10.1016/0014-5793(86)80126-0. 

[edit] External links

The CAS registry number for this enzyme class is 37205-42-8.

• IUBMB entry for 4.1.1.71

• KEGG entry for 4.1.1.71

• BRENDA entry for 4.1.1.71

• NiceZyme view of 4.1.1.71

• EC2PDB: PDB structures for 4.1.1.71

• PRIAM entry for 4.1.1.71

• PUMA2 entry for 4.1.1.71

• IntEnz: Integrated Enzyme entry for 4.1.1.71

• MetaCyc entry for 4.1.1.71

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008683: 2-oxoglutarate decarboxylase

• AMIGO entry for GO code 0008683: 2-oxoglutarate decarboxylase