2-furoyl-CoA dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a 2-furoyl-CoA dehydrogenase (EC 1.3.99.8) is an enzyme that catalyzes the chemical reaction

2-furoyl-CoA + H₂O + acceptor S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor

The 3 substrates of this enzyme are 2-furoyl-CoA, H₂O, and acceptor, whereas its two products are S-(5-hydroxy-2-furoyl)-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating). Other names in common use include furoyl-CoA hydroxylase, 2-furoyl coenzyme A hydroxylase, 2-furoyl coenzyme A dehydrogenase, and 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating). It employs one cofactor, copper.

[edit] References

• IUBMB entry for 1.3.99.8
• BRENDA references for 1.3.99.8 (Recommended.)
• PubMed references for 1.3.99.8
• PubMed Central references for 1.3.99.8
• Google Scholar references for 1.3.99.8
• Kitcher JP, Trudgill PW, Rees JS (1972). "Purification and properties of 2-furoyl-coenzyme A hydroxylase from Pseudomonas putida F2". Biochem. J. 130: 121–32. PMID 4655411. 

[edit] External links

The CAS registry number for this enzyme class is 9068-18-2.

• IUBMB entry for 1.3.99.8

• KEGG entry for 1.3.99.8

• BRENDA entry for 1.3.99.8

• NiceZyme view of 1.3.99.8

• EC2PDB: PDB structures for 1.3.99.8

• PRIAM entry for 1.3.99.8

• PUMA2 entry for 1.3.99.8

• IntEnz: Integrated Enzyme entry for 1.3.99.8

• MetaCyc entry for 1.3.99.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047542: 2-furoyl-CoA dehydrogenase

• AMIGO entry for GO code 0047542: 2-furoyl-CoA dehydrogenase