2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
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In enzymology, a 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase (EC 3.5.1.66) is an enzyme that catalyzes the chemical reaction
- 2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O
acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH3 + CO2
Thus, the two substrates of this enzyme are 2-(hydroxymethyl)-3-(acetamidomethylene)succinate and H2O, whereas its 4 products are acetate, 2-(hydroxymethyl)-4-oxobutanoate, NH3, and CO2.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). Other names in common use include compound B hydrolase, alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid, and hydrolase. This enzyme participates in vitamin b6 metabolism.
[edit] References
- IUBMB entry for 3.5.1.66
- BRENDA references for 3.5.1.66 (Recommended.)
- PubMed references for 3.5.1.66
- PubMed Central references for 3.5.1.66
- Google Scholar references for 3.5.1.66
- Huynh MS, Snell EE (1985). "Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260: 2379–83. PMID 3972793.
[edit] External links
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- The CAS registry number for this enzyme class is 95829-26-8.
[edit] Gene Ontology (GO) codes
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