2-(acetamidomethylene)succinate hydrolase

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In enzymology, a 2-(acetamidomethylene)succinate hydrolase (EC 3.5.1.29) is an enzyme that catalyzes the chemical reaction

2-(acetamidomethylene)succinate + 2 H₂O $\rightleftharpoons$ acetate + succinate semialdehyde + NH₃ + CO₂

Thus, the two substrates of this enzyme are 2-(acetamidomethylene)succinate and H₂O, whereas its 4 products are acetate, succinate semialdehyde, NH₃, and CO₂.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). This enzyme is also called alpha-(N-acetylaminomethylene)succinic acid hydrolase. This enzyme participates in vitamin b6 metabolism.

[edit] References

IUBMB entry for 3.5.1.29
BRENDA references for 3.5.1.29 (Recommended.)
PubMed references for 3.5.1.29
PubMed Central references for 3.5.1.29
Google Scholar references for 3.5.1.29
Huynh MS, Snell EE (1985). "Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260: 2379–83. PMID 3972793.
Nyns EJ, Zach D, Snell EE (1969). "The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid". J. Biol. Chem. 244: 2601–5. PMID 5769993.