2,6-dioxo-6-phenylhexa-3-enoate hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a 2,6-dioxo-6-phenylhexa-3-enoate hydrolase (EC 3.7.1.8) is an enzyme that catalyzes the chemical reaction

2,6-dioxo-6-phenylhexa-3-enoate + H₂O $\rightleftharpoons$ benzoate + 2-oxopent-4-enoate

Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexa-3-enoate and H₂O, whereas its two products are benzoate and 2-oxopent-4-enoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase. This enzyme is also called HOHPDA hydrolase. This enzyme participates in biphenyl degradation and fluorene degradation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1C4X, 1J1I, and 2OG1.

[edit] References

IUBMB entry for 3.7.1.8
BRENDA references for 3.7.1.8 (Recommended.)
PubMed references for 3.7.1.8
PubMed Central references for 3.7.1.8
Google Scholar references for 3.7.1.8
Omori T, Sugimura K, Ishigooka H and Minoda Y (1986). "Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl". Agric. Biol. Chem. 50: 931–937.