2,3-dimethylmalate lyase

From Wikipedia, the free encyclopedia

In enzymology, a 2,3-dimethylmalate lyase (EC 4.1.3.32) is an enzyme that catalyzes the chemical reaction

(2R,3S)-2,3-dimethylmalate propanoate + pyruvate

Hence, this enzyme has one substrate, (2R,3S)-2,3-dimethylmalate, and two products, propanoate and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming). Other names in common use include 2,3-dimethylmalate pyruvate-lyase, and (2R,3S)-2,3-dimethylmalate pyruvate-lyase. This enzyme participates in c5-branched dibasic acid metabolism.

[edit] References

• IUBMB entry for 4.1.3.32
• BRENDA references for 4.1.3.32 (Recommended.)
• PubMed references for 4.1.3.32
• PubMed Central references for 4.1.3.32
• Google Scholar references for 4.1.3.32
• Pirzer P, Lill U, Eggerer H (1979). "Nicotinic acid metabolism. 2,3-Dimethylmalate lyase". Hoppe. Seylers. Z. Physiol. Chem. 360: 1693–702. PMID 527937. 
• Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006). "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U. S. A. 103: 12341–6. PMID 16894175. 

[edit] External links

The CAS registry number for this enzyme class is 73562-28-4.

• IUBMB entry for 4.1.3.32

• KEGG entry for 4.1.3.32

• BRENDA entry for 4.1.3.32

• NiceZyme view of 4.1.3.32

• EC2PDB: PDB structures for 4.1.3.32

• PRIAM entry for 4.1.3.32

• PUMA2 entry for 4.1.3.32

• IntEnz: Integrated Enzyme entry for 4.1.3.32

• MetaCyc entry for 4.1.3.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047529: 2,3-dimethylmalate lyase

• AMIGO entry for GO code 0047529: 2,3-dimethylmalate lyase