1-acylglycerophosphocholine O-acyltransferase

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In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine CoA + 1,2-diacyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.23
• BRENDA references for 2.3.1.23 (Recommended.)
• PubMed references for 2.3.1.23
• PubMed Central references for 2.3.1.23
• Google Scholar references for 2.3.1.23
• Bell RM, Coleman RA (1980). "Enzymes of glycerolipid synthesis in eukaryotes". Annu. Rev. Biochem. 49: 459–87. doi:10.1146/annurev.bi.49.070180.002331. PMID 6250446. 
• Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine". Biochim. Biophys. Acta. 152: 645–8. PMID 5661029. 
• Miki Y, Hosaka K, Yamashita S, Handa H, Numa S (1977). "Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes". Eur. J. Biochem. 81: 433–41. doi:10.1111/j.1432-1033.1977.tb11968.x. PMID 598375. 
• van den Bosch H, van Golde LM, Eibl H, van Deenen LL (1967). "The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes". Biochim. Biophys. Acta. 144: 613–23. PMID 6078124. 

[edit] External links

The CAS registry number for this enzyme class is 9027-64-9.

• IUBMB entry for 2.3.1.23

• KEGG entry for 2.3.1.23

• BRENDA entry for 2.3.1.23

• NiceZyme view of 2.3.1.23

• EC2PDB: PDB structures for 2.3.1.23

• PRIAM entry for 2.3.1.23

• PUMA2 entry for 2.3.1.23

• IntEnz: Integrated Enzyme entry for 2.3.1.23

• MetaCyc entry for 2.3.1.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047184: 1-acylglycerophosphocholine O-acyltransferase

• AMIGO entry for GO code 0047184: 1-acylglycerophosphocholine O-acyltransferase