1-acylglycerol-3-phosphate O-acyltransferase

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In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

[edit] References

• IUBMB entry for 2.3.1.51
• BRENDA references for 2.3.1.51 (Recommended.)
• PubMed references for 2.3.1.51
• PubMed Central references for 2.3.1.51
• Google Scholar references for 2.3.1.51
• Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts". Eur. J. Biochem. 129: 629–36. PMID 6825679. 
• Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine". Biochim. Biophys. Acta. 152: 645–8. PMID 5661029. 
• Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38: 25–31. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123. 

[edit] External links

The CAS registry number for this enzyme class is 51901-16-7.

• IUBMB entry for 2.3.1.51

• KEGG entry for 2.3.1.51

• BRENDA entry for 2.3.1.51

• NiceZyme view of 2.3.1.51

• EC2PDB: PDB structures for 2.3.1.51

• PRIAM entry for 2.3.1.51

• PUMA2 entry for 2.3.1.51

• IntEnz: Integrated Enzyme entry for 2.3.1.51

• MetaCyc entry for 2.3.1.51

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003841: 1-acylglycerol-3-phosphate O-acyltransferase

• AMIGO entry for GO code 0003841: 1-acylglycerol-3-phosphate O-acyltransferase