(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
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In enzymology, a (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase (EC 2.1.1.115) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
Thus, the two substrates of this enzyme are S-adenosyl methionine and (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline, whereas its two products are S-adenosylhomocysteine and N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This enzyme is also called norreticuline N-methyltransferase. This enzyme participates in alkaloid biosynthesis i.
[edit] References
- IUBMB entry for 2.1.1.115
- BRENDA references for 2.1.1.115 (Recommended.)
- PubMed references for 2.1.1.115
- PubMed Central references for 2.1.1.115
- Google Scholar references for 2.1.1.115
- Frenzel T, Zenk MH (1990). "Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures". Phytochemistry 29: 3491–3497. doi:.
[edit] External links
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- The CAS registry number for this enzyme class is 132084-82-3.
[edit] Gene Ontology (GO) codes
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