(R)-3-amino-2-methylpropionate-pyruvate transaminase

From Wikipedia, the free encyclopedia

In enzymology, a (R)-3-amino-2-methylpropionate-pyruvate transaminase (EC 2.6.1.40) is an enzyme that catalyzes the chemical reaction

(R)-3-amino-2-methylpropanoate + pyruvate $\rightleftharpoons$ 2-methyl-3-oxopropanoate + L-alanine

Thus, the two substrates of this enzyme are (R)-3-amino-2-methylpropanoate and pyruvate, whereas its two products are 2-methyl-3-oxopropanoate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is (R)-3-amino-2-methylpropanoate:pyruvate aminotransferase. Other names in common use include D-3-aminoisobutyrate-pyruvate transaminase, beta-aminoisobutyrate-pyruvate aminotransferase, D-3-aminoisobutyrate-pyruvate aminotransferase, D-3-aminoisobutyrate-pyruvate transaminase, (R)-3-amino-2-methylpropionate transaminase, and D-beta-aminoisobutyrate:pyruvate aminotransferase.

[edit] References

IUBMB entry for 2.6.1.40
BRENDA references for 2.6.1.40 (Recommended.)
PubMed references for 2.6.1.40
PubMed Central references for 2.6.1.40
Google Scholar references for 2.6.1.40
Kakimoto Y, Taniguchi K, Sano I (1969). "D-beta-aminoisobutyrate:pyruvate aminotransferase in mammalian liver and excretion of beta-aminoisobutyrate by man". J. Biol. Chem. 244: 335–40. PMID 5773299.
Tamaki N, Sakata SF, Matsuda K (2000). "Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver". Methods. Enzymol. 324: 376–89. PMID 10989446.