(phosphorylase) phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a [phosphorylase] phosphatase (EC 3.1.3.17) is an enzyme that catalyzes the chemical reaction

[phosphorylase a] + 4 H₂O 2 [phosphorylase b] + 4 phosphate

Thus, the two substrates of this enzyme are [[[phosphorylase a]]] and H₂O, whereas its two products are [[[phosphorylase b]]] and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [phosphorylase a] phosphohydrolase. Other names in common use include PR-enzyme, phosphorylase a phosphatase, glycogen phosphorylase phosphatase, protein phosphatase C, and type 1 protein phosphatase.

[edit] References

• IUBMB entry for 3.1.3.17
• BRENDA references for 3.1.3.17 (Recommended.)
• PubMed references for 3.1.3.17
• PubMed Central references for 3.1.3.17
• Google Scholar references for 3.1.3.17
• Brandt H, Capulong ZL, Lee EY (1975). "Purification and properties of rabbit liver phosphorylase phosphatase". J. Biol. Chem. 250: 8038–44. PMID 240850. 
• GRAVES DJ, FISCHER EH, KREBS EG (1960). "Specificity studies on muscle phosphorylase phosphatase". J. Biol. Chem. 235: 805–9. PMID 13829077. 
• RALL TW, WOSILAIT WD, SUTHERLAND EW (1956). "The interconversion of phosphorylase a and phosphorylase b from dog heart muscle". Biochim. Biophys. Acta. 20: 69–76. PMID 13315351. 

[edit] External links

The CAS registry number for this enzyme class is 9025-74-5.

• IUBMB entry for 3.1.3.17

• KEGG entry for 3.1.3.17

• BRENDA entry for 3.1.3.17

• NiceZyme view of 3.1.3.17

• EC2PDB: PDB structures for 3.1.3.17

• PRIAM entry for 3.1.3.17

• PUMA2 entry for 3.1.3.17

• IntEnz: Integrated Enzyme entry for 3.1.3.17

• MetaCyc entry for 3.1.3.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050196: [phosphorylase phosphatase]

• AMIGO entry for GO code 0050196: [phosphorylase phosphatase]